3 edition of RNA therapeutics found in the catalog.
Includes bibliographical references and index.
|Statement||edited by Mouldy Sioud|
|Series||Methods in molecular biology -- 629, Springer protocols, Methods in molecular biology (Clifton, N.J.) -- v. 629., Springer protocols|
|LC Classifications||RM666.R554 R53 2010|
|The Physical Object|
|Pagination||xvi, 526 p. :|
|Number of Pages||526|
|ISBN 10||1607616564, 1607616572|
|ISBN 10||9781607616566, 9781607616573|
|LC Control Number||2010921201|
RNA therapeutics uses a technology called RNA interference (RNAi) which has rapidly advanced over the past few years and generated a great deal of interest from biotech investors. RNAi is a gene-silencing technology that turns on and off the genes that regulate proteins in people’s cells. Drugs being developed based on this technology have recently advanced, mostly due to improved delivery. According to a review of RNA-based therapeutics in Genetic Engineering & Biotechnology News, there are many RNA therapeutics currently in the drug development pipeline. For example, RXI, the lead sd-rxRNA compound developed by RXI Pharmaceuticals, was designed to specifically silence the CTGF protein to reduce dermal and ocular scarring.
Also, the book contains several excellent reviews for teaching itative and comprehensive, RNA Therapeutics: Function, Design, and Delivery provides key models and tools which will assist researchers in increasing our understanding of RNA functions, modifications, and their involvement in diseases in order to lead to the design of. RNA-based therapeutics must be delivered to the target cell and enter the cell to be active (8) (Figure 1). Overcoming delivery of RNAs across the lipid bilayer and into cells remains a major challenge (3). Furthermore, once internalised, the endocytic pathway – a major cellular active uptake mechanism for agents too large to permeate.
Serendipitously, as progress in developing these novel therapeutics was recorded, the opportunities for RNA targeting multiplied as new classes of RNAs and new roles for RNAs were discovered (Cech and Steitz, , Matsui and Corey, ; see Figure 1). The purpose of this review is to summarize the current status of the technology and to Cited by: RNA Interference Therapeutics and Human Diseases: /ch Defective protein synthesis leads to diseases. If protein synthesis can be controlled, disease causing molecules can be tailored in some way. This is theAuthor: Dolly Sharma, Shailendra Singh, Trilok Chand.
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Authoritative and comprehensive, RNA Therapeutics: Function, Design, and Delivery provides key models and tools which will assist researchers in increasing our understanding of RNA functions, modifications, and their involvement in diseases in order to lead to the design of vital new RNA-based : Mouldy Sioud.
RNA Therapeutics (Topics in Medicinal Chemistry): Medicine & Health Science Books @ mat: Hardcover. Also, the book contains several excellent reviews for teaching purposes. Authoritative and comprehensive, RNA Therapeutics: Function, Design, and Delivery provides key models and tools which will assist researchers in increasing our understanding of RNA functions, modifications, and their involvement in diseases in order to lead to the design of vital new RNA-based therapeutics.
RNA Therapeutics. Editors: Garner, Amanda L. (Ed.) Usually dispatched within 3 to 5 business days. Usually dispatched within 3 to 5 business days.
Medicinal chemistry is both science and art. The. RNA Nanotechnology and Therapeutics - CRC Press Book Interest in RNA nanotechnology has increased in recent years as recognition of its potential for applications in nanomedicine has grown.
Edited by the world's foremost experts in nanomedicine, this comprehensive, state-of-the-art reference details the latest research developments and challenges in t.
This book is unique in that it covers a very broad spectrum of topics related to RNA nanotechnology, yet it maintains a focus on constructing and analyzing RNA nanoparticles.
It introduces the reader to the basics of RNA structure, and discusses functions of various natural RNAs, from small molecules to large molecular machines such as the ribosome. RNA Nanotechnology and Therapeutics book.
Edited By Peixuan Guo, Farzin Haque. Edition 1st Edition. First Published eBook Published 9 July Pub. location Boca Raton. Interest in RNA nanotechnology has increased in recent years as recognition of its potential for applications in nanomedicine has grown.
Edited by the world's Cited by: RNA Nanotechnology and Therapeutics: Methods and Protocols Peixuan Guo, Farzin Haque This volume contains a compilation of techniques and laboratory protocols directly related to RNA nano technology and its applications in nano biotechnology and nano medicine.
Recent advances in polymeric materials for the delivery of RNA therapeutics 12 September | Expert Opinion on Drug Delivery, Vol. 16, No. 11 The current state and future directions of RNAi-based therapeuticsCited by: 4. The RNA Promise Developing Breakthrough RNA Therapeutics By interweaving nucleic acid scientists with clinicians dedicated to finding new cures, our goal is to create a new paradigm for organizing molecular research that enables the rapid application of new biological discoveries to solutions for unmet challenges in human health.
Introduction. Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs.
Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. In RNA Therapeutics: Function, Design, and Delivery, expert contributors from a broad spectrum of scientific backgrounds highlight the roles that messenger RNAs and small RNAs can play in biology and medicine.
While covering the five major RNA-based drugs, namely the use of ribozymes to cleave and/or correct mRNA transcript, the use of siRNA. Buy RNA Therapeutics: Function, Design, and Delivery: (Methods in Molecular Biology) by Sioud, Mouldy (ISBN: ) from Amazon's Book Store. Everyday low prices and free delivery on eligible : Hardcover.
RNA-based therapeutics can be classified by the mechanism of activity, and include inhibitors of mRNA translation (antisense), the agents of RNA interference (RNAi), catalytically active RNA molecules (ribozymes), and RNAs that bind proteins and other molecular ligands (aptamers).Cited by: 1.
Introduction to RNAi. RNA interference (RNAi) is a regulatory mechanism of most eukaryotic cells that uses small double stranded RNA (dsRNA) molecules to direct homology-dependent control of gene activity .Known as small interfering RNAs (siRNA) these ∼ bp long dsRNA molecules have a characteristic 2 nucleotide 3' overhang that allows them to be recognized by the Cited by: RNA therapies that target proteins use a type of molecule known as an RNA aptamer.
The molecule is designed to bind to a specific site on a specific protein to modulate its : Sarah DeWeerdt. mRNA is a fundamental component of gene expression.
It is the key link in the process of translating genetic information encoded in DNA into instructions that are used by cells to produce the proteins needed to carry out essential cellular functions.
These instructions are processed through cellular mechanisms in two steps: transcription and translation. Authoritative and comprehensive, RNA Therapeutics: Function, Design, and Delivery provides key models and tools which will assist researchers in increasing our understanding of RNA functions, modifications, and their involvement in diseases in order to lead to the design of vital new RNA-based therapeutics.
Contenu 1. RNA Modifications: A. Read "RNA Therapeutics" by available from Rakuten Kobo. Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for Price: $ As the clinical potential of RNA therapeutics begins to be unveiled, expanding the range of tissue types that can be targeted for delivery of these drugs is now the main hurdle to overcome.
SMi Group announces the 10th Annual RNA Therapeutics Conference in London on February 20 th – 21 st Undoubtedly, the field of RNA therapeutics is currently undergoing a major expansion, and the potential for using RNA drugs for personalised medicines and immunotherapy, as well as to address genetic, infectious and chronic diseases will.The strengths and weaknesses of RNA therapeutics.
Taking a leaf out of Spinraza’s book, inDr. Timothy Yu and his colleagues from Boston Children’s Hospital designed an oligonucleotide to treat a rare and fatal neurodegenerative condition called Batten disease in a 6-year-old patient, Mila Makovec.
What followed was a race to.\/ Mouldy Sioud -- Using OligoWalk to identify efficient siRNA sequences \/ David H. Mathews -- Jet-injections of short hairpin RNA-encoding vectors into tumor cells \/ Wolfgang Walther, Ulrike Stein, and Hermann Lage -- Short hairpin RNA (shRNA): design, delivery, and assessment of gene knockdown \/ Chris B.
Moore [and others] -- Effective.